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All subjects were entered on an intent-to-treat basis, with last observation carried forward (LOCF) for subjects who terminated study participation prematurely [ 51, 52].
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This has included information on citizenship, status (e.g., full or part-time), the date the student commenced studies, their degree program and field of study, and the date the student terminated studies.
The pooled RR of the early terminated studies suggests a deleterious effect of HFOV on ARDS patients.
12 Not publishing negative or prematurely terminated studies is problematic for assessing clinical efficacy and supporting rational decision making.
In addition, HFOV significantly increased mortality in ARDS in two early terminated studies (RR 1.33; 95% CI 1.09 to 1.62; P <0.01) (Additional file 4) [ 14, 18].
Students who wish to terminate study in a graduate program should submit a properly endorsed Request to Permanently Withdraw from Degree Program form to the Student Services Center.
Major deviations from baseline levels along with clinical symptoms will terminate study drug application.
Sites are encouraged to obtain a final measure of the primary endpoint as soon as possible in patients terminating study medication prematurely.
Critical to the proper field testing of these devices is an in-country institutional review board with the authority to approve and terminate studies.
22 Owing to regional insecurity, the study investigators terminated the study early after a 4-week period of data collection.
Gilead reviewed the unblinded data and terminated this study in agreement with the DMC recommendation and in consultation with the US Food and Drug Administration FDAA).
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