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Although these results fulfilled the planned settings to proceed to the second stage, the coordinating committee decided to terminate this study because single agent activity did not appear to be very promising for this cohort of patients.
The CIs may terminate this study prematurely, either in its entirety or either of the sites, for reasonable causes (e.g. unsatisfactory enrolment with respect to quantity or quality, inaccurate or incomplete data collection, falsification of records, failure to adhere to protocol).
These results did not comply with the <1 response out of 15 patients to declare the ineffectiveness of this drug to the targeted cohort of patients in the first stage; however, the coordinating committee decided to terminate this study because single agent activity did not appear to be very promising for this cohort of patients.
The CIs may terminate this study prematurely, either in its entirety or at individual study centres, for reasonable causes (e.g. unsatisfactory enrolment with respect to quantity or quality, inaccurate or incomplete data collection, falsification of records, failure to adhere to protocol).
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Thus we terminated this study.
In view of the lower than the pre-determined RR (see Statistical Methods) for further patient accrual, we decided to terminate the study at this stage.
Baseline patient and tumor characteristics including number, size, location of treated lesions, immune status, exposure to previous, and subsequent treatments, RT date, response to treatment, acute and late toxicity were recorded until last follow-up, death of the patient, or the data collection was terminated for this study on 13 May 2013.
Spinardi suggests that STRAT-X was allowed to proceed so it could terminate the study for such a missile.
The DMC recommended that the trial be stopped; we thus decided to prematurely terminate the study in November 2005.
The DMC recommended that the trial be stopped, and we decided to terminate the study prematurely in August 2006.
Nevertheless, the trial steering committee decided to terminate the study.
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