At the end of the experiments the rats were again anaesthetised, the thorax opened, vena cava inferior cut open and the rats were terminated by bleeding.
PCC has been successfully used to terminate serious bleeding in pre-clinical studies [ 22- 24].
Owing to the conflicting data concerning such therapy, we investigated the impact of a four-factor PCC to terminate massive bleeding following the infliction of multiple trauma in dabigatran anticoagulated pigs.
Topical hemostatic agents composed of a gelatin-based matrix and thrombin have been reported to be effective, in addition to traditional means, in terminating bleeding during cardiac operations.
In total, 43 thrombolytic procedures (5·7 per cent) were terminated because of bleeding complications.
We determined that after four injections, a sufficient titer was achieved for both immunogens (OD reading of the sera of the fourth injection was at saturation at 1 200 dilution), and terminating bleeds were performed.
During the third part pneumoperitoneum was again established and laparoscopy was performed again to remove potentially pooled blood in the rectouterine excavation as well as to terminate any existing bleeding of the vaginal cuff suture.
R: My husband was also sure that the pregnancy was terminated when it started bleeding; we thought it was over… I: When did you know that you were still pregnant?
Prothrombin complex concentrate (PCC) has been suggested as a measure to terminate trauma and dabigatran-induced bleeding.
Warning signs to terminate exercise are; vaginal bleeding, dyspnoea before exertion, dizziness, headache, chest pain, muscle weakness, calf pain or swelling, preterm labour, decreased foetal movement, amniotic fluid leakage [ 26].
