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BCR 1,9 2,0 0,6 Source: Authors' elaborations aFinancial costs for investment in terminals (necessary adjustments of the intermodal terminals for the implementation of the container-mover technology): investment in terminal infrastructure: 300.000 € per terminal; investment in terminal equipment: 1.000.000 € per terminal.
The investments in terminals (necessary for enabling the operation of SPECTRUM trains in an efficient manner): it was pointed out how the innovative concepts of SPECTRUM trains, could not exploit their potential in making rail freight supply chain more efficient if terminals (e.g. in a selected route/corridor) do not adapt their layout and organization.
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In order to attain high efficiency, carefully matched loading and unloading terminals are necessary.
In addition, the classification process is labor and capital intensive since many workers and large quantities of equipment are needed to sort the traffic, and construction and maintenance of large terminals are necessary to handle the sorting task.
Clearly, geographical overlap between presynaptic and postsynaptic terminals is necessary for synaptic connections to form, and our experiments suggest that dendritic positioning mechanisms contribute to the emergence of connectivity.
Thus future studies with markers that can differentiate between DA terminal innervation and DAT expression per terminal are necessary to confirm our findings.
To provide such features, hydrophobic amino acids at the C-terminal and basic amino acids at the N-terminal are necessary.
Although cubilin lacks a classic transmembrane domain and cytoplasmic tail, the amino-terminal end is necessary for membrane anchoring [ 35].
However, our results show that the N-terminal domain of dRecQ4, dRecQ4△868 1579 (Figure 8), which is homologous to the xRecQ4 N-terminal domain, necessary and sufficient for DNA replication in Xenopus [20], [21], does not rescue the animal's lethality.
Terminal operations necessary to tranship the goods from one mode to another imply a vertical leap in the cost curve.
In the centric diatom Thalassiosira pseudonana the Psb28 protein is encoded in the plastid genome while a second version is nuclear-encoded and possesses a bipartite N-terminal presequence necessary to target the protein into the diatom complex plastid.
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