In normal animals, TSCs have important relationships with motor terminals that include the ability to induce sprouting [28] and mechanisms that influence synaptic release [29].
We found that PC12 cells display two different kinds of neurite terminals: while some neurites are tipped by proper growth cones, most neurites display the enlarged hybrid terminals that include a varicosity.
The data is in concordance with the prevailing model of medullary TEC terminal differentiation that includes the post-Aire stage.
Within the Antennariidae, Antennarius striatus is recovered as the sister of a terminal clade that includes Histrio histrio and A. coccineus, thus rendering Antennarius paraphyletic.
Previously reported human AMELX mutations include those resulting in a total loss of secreted protein (e.g. nonsense mutation in the signal peptide); mutations causing loss of the amelogenin C-terminal, and mutations affecting the amelogenin N-terminal region that includes a lectin-like, tri-tyrosyl domain reported to bind to N-acetyl d-glucosamine (14).
Most phytochromes share a common architecture consisting of an N-terminal photosensor that includes the PAS2 GAF PHY domain triad and a C-terminal variable output module.
The C-terminal half of the DG core protein is highly-conserved, yet the N-terminal region, that includes the laminin-binding region, has undergone major lineage-specific divergences.
Like other M proteins, M5 has an N-terminal hypervariable region (HVR), which is the target for opsonizing antibodies, and a C-terminal part that includes a relatively conserved C-repeat region [2], [19].
Like other VAPs, the Giardia VAP protein contains an N-terminal domain that includes the VAP consensus sequence [55], a central coiled-coil domain and a C-terminal transmembrane domain with the putative dimerization motif GxxxG (Fig. S8).
PABP domain structure consists of an amino-terminal domain that includes four distinct RNA recognition motifs (RRM1-4), followed by a linker region and a carboxy-terminal domain known as MLLE (formerly CTC or PABC).
