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Most of this terminal repression is carried out by tll, while the only known non-redundant role of hkb in gap gene patterning consists of positioning the posterior boundary of the posterior hb domain (Ashyraliyev et al., 2009; Jaeger, 2011).
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Rao, G. et al. Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
We previously showed that Barx2 contains both an N-terminal repression domain and a C-terminal activation domain [36] that may recruit various co-repressors and co-activators respectively.
The C-terminal repression domain associates with a novel protein called CoREST (Andres et al. 1999).
It is possible that BRCA1 interacts with other transcription factors through its carboxy-terminal repression domain in the regulation of the IGF-1 promoter.
The function of carboxy-terminal repression domain of BRCA1 is not well understood yet, but BRCA1 interacts with several factors through this domain.
These results suggest that the carboxy-terminal repression domain of BRCA1 is further required to suppress E2-dependent ER α transactivation of IGF-1 promoter.
These results suggest that the intact carboxy-terminal repression domain has important functions in suppressing E2-induced IGF-1 reporter activity.
The eh1 motifs are present in the C-terminal repression domains of mouse and chick FoxD3 [ 30, 31], and Xenopus FoxD5 [ 32], as well as the C-terminal transcriptional inhibitory domain of mouse FoxC1 [ 33].
Subsequently, we removed the first three exons, including the start codon, the N-terminal repression domain, nuclear localization signal and part of the T-box domain, using a βactin-Cre deleter strain to create a Tbx22 null allele.
A splice variant of FIR within the N-terminal repression domain was recently identified in human colorectal cancers but not in adjacent normal tissue (Matsushita et al, 2006), underscoring FIR's role in c-myc regulation.
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