Exact(16)
The specially designed adaptor with asymmetric strands and terminal modification avoids amplification of non-target DNA sequences.
A homogeneous BHJ structure based on oligothiophene and fullerene has been fabricated by means of terminal modification using the sterically bulky t-butyl group.
The C terminal and N terminal modification with the sequence G-DOPA-G shows similar adsorption rate and mass adsorption coverage at saturation; however it is presented a more loosely layers on the G-DOPA-G-TeT-124.
No significant influence of the G-DOPA-G N- and C- terminal modification in the peptide regarding mass adsorption behavior was observed; in both cases a higher adsorption is achieved in comparison to the Tet-124 peptide without the G-DOPA-G modification.
The design of chemical structures of polyanionic cyclodextrin, optimization of their addition concentrations, and selection of hydroxyl compounds coexisting with them are critical for this simple and easy method for polymer length control and terminal modification of epsilon-poly-l-lysine.
To investigate the role of lysosomal H2O2 involved in cerebral I-R injury, we designed and synthesized a lysosome-targetable two-photon fluorescent probe ztl-4, through expansion and substitution of the original pyridazinone scaffold, conjugation of electronic-donating aromatic ring and precise terminal modification of the alkyl linker.
Similar(44)
15 In a model ligation reaction, successful thioester formation and in situ NCL with Cys terminated EPO residues 161 166 was observed, thus opening the door to selective C-terminal modification of bacterially produced EPO, which has not been previously achieved.
This N-terminal modification has a great impact on dihydroceramide Δ4-desaturase activity.
Protein expression was clearly affected by N-terminal modification, but there was no evidence that the modification affected protein activity.
This N-terminal modification enhances the solubility of the recombinant protein in E. coli (Butt et al. 2005) and aids in its chromatographic separation (see below).
These peptide aptamers retained their binding properties to PrPc and, depending on peptide sequence and C-terminal modification, interfered with endogenous PrPScconversion upon expression in prion-infected cells.
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