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Three compositions of the digestion products are adenosine (Ado), ribosyladenosine (R-Ado) and diribosyladenosine (R2-Ado), which represent the terminal, linear, or branched PAR, respectively.
The effect of terminal linear chains (like hexyloxy, octyloxy, and hexadecyloxy chains) on their photophysical (solvatochromism and aggregation induced emission (AIE)) and electrochemical properties were systematically investigated.
Prior to mass spectrometry, the extracted PAR chains from the wild-type MEFs or the Parp2−/− MEFs were treated with venom pyrophophatase (PPase) and alkaline phosphatase (AP) to generate adenosine (Ado), ribosyladenosine (R-Ado) and diribosyladenosine (R2-Ado), which represent the terminal, linear, or branched unit in PAR chain, respectively (Supplementary Figure 2A and 2B).
In this study, novel series of thioureido-benzenesulfonamide derivatives bearing an enaminone linker either meta or para oriented and having terminal linear or substituted aromatic or heteroaromatic ring system 5 16a,b were designed and synthesized based on the general pharmacophoric features of type II VEGFR2 inhibitors.
The half-life of the terminal phase (t1/2 Z ) was calculated as loge 2/ λz, where λz is the elimination rate constant calculated from the terminal linear portion of the log of the concentration in plasma.
The terminal (first-order) elimination rate constant (λz) was calculated from the slope of the terminal linear portion of the log concentration vs time curve by linear regression analysis.
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The resulting HER glyco-peptide (HER-GP) was then linked to a palmitic acid moiety, attached either at the N-terminal end (linear HER-GLP-1) or in the middle between the CD4+ and CD8+ T cell epitopes (branched HER-GLP-2).
We suggest a membrane-dependent mode of action for latartoxins with their C-terminal linear modules acting as anchoring devices.
Using the non-equilibrium Keldysh Green's function technique, electron transport properties through a two-terminal linear tri-quantum-dot molecule Aharonov-Bohm (A-B) interference are investigated.
The interesting feature of the new toxins is their modular organization: they contain an N-terminal cysteine-rich (knottin or ICK) region as in many neurotoxins from spider venoms and a C-terminal linear part alike some cytolytic peptides.
This N-terminal linear peptide exhibited a similar and dose-dependent cytotoxic effect both in OSCC cell lines (64.4% and 60% for CAL27 and SCC15, resp).
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