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[11C]DTBZ binding informs on the density of VMAT2, from which DA terminal integrity (i.e., denervation severity) may be inferred [11, 12].
To assess 5-HT axon terminal integrity after MDMA treatment, the density of 5-HT transporter (SERT) binding sites was measured by quantitative autoradiography using [125I]RTI-55 -2beta- 4-iodophenyl3 beta- 4-iodophenyl) tropane) (125I-RTI-55) as a ligand.
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These observations suggested that the N-terminal domain of TPX2 was required to promote spindle pole integrity and robustness.
In fact, nerve action potential generation and terminal axon structural integrity are critically dependent on axonal transport of proteins and other molecules [ 46].
The ability of PTEN to decrease neuronal spine density depended upon the phosphorylation status of serine and threonine residues in its C-terminal segment and the integrity of the C-terminal PDZ-binding motif.
Here we show that compromising Carboxy-Terminal Modulator Protein (CTMP) integrity by preventing its N-terminal cleavage by point mutation or by a knockdown approach affected mitochondrial network organization in cells.
Subsequently, the genome of rHJOpac-F was investigated via Southern-blot analysis, at the terminal junction, for complete integrity, and for the absence of any pBeloBAC11 sequences.
The operator verified the black terminal marker indicating tip integrity was present.
At the same time, the integrity of the terminal web is not required for the establishment and maintenance of the epithelial polarity, since the general organization of the apical domain and the junctional integrity are not affected.
We propose that the globular N-terminal domain of Psu confers structural integrity to the functionally important C-terminal tail, which interacts directly with the hexameric Rho.
Deletion of CSPα is ultimately linked to a state where the integrity of synaptic terminals is compromised.
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