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Widespread destruction of serotonergic terminal fields or regionally specific terminal field destruction was achieved using intracerebroventricular and more target specific infusions of 5,7-dihydroxytryptamine.
Moreover, epigenetic activation of the hippocampal BDNF in the HRs following ESS exposure was accompanied by increase in the supra-pyramidal mossy fibre (SP-MF) and total mossy fibre terminal field volumes compared to handled controls.
Comparing these experimental data with the results of modeling the otolith structures of vertebrates indicates that some peculiarities of the neural responses may be explained by the spatial dependence of the material parameters of the otolithic membrane across its thickness and within the volume of the membrane corresponding to the terminal field.
The incertotectal terminal field in the cat is less dense than that observed previously in the rat, suggesting species differences in the development of this pathway.
The goal of this study was to define the anatomical relationships between the terminal field of the nigrotectal pathway and the tectal neurons which project to contralateral brainstem gaze centers by way of the predorsal bundle.
Anterograde tracers demonstrated that the incertotectal terminal field is most dense in the intermediate gray layer, which is the primary source of the descending pathway from the superior colliculus to brainstem gaze centers.
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Axons that terminated in the magnocellular layers had significantly larger fiber diameters and wider terminal fields than those that terminated in the parvocellular layers.
Transganglionic tracing studies have revealed the detailed somatotopy of primary afferent terminal fields in brainstem and spinal cord.
We also observed intense mCherry-labeled terminal fields in the ventrolateral and lateral periaqueductal gray matter (lPAG) and the adjacent lateral pontine tegmentum, a key region for REM sleep regulation29.
A schematic of the rostral-caudal distribution of axon terminal fields in the dCA3 (Fig. 7f, g) and DG (Fig. 7j, k) from a representative double hit animal are displayed.
Results revealed robust axon terminal fields in the dCA3 (Fig. 7d, e) and DG (Fig. 7h, i) for each of the three animals that were confirmed as double hits in both injection sites.
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