Sentence examples for terminal disposition from inspiring English sources

Thereafter, the concentration time profile turned into a slow terminal disposition phase.

A slower terminal disposition phase became visible at doses of 1 mg/kg and higher.

After the rapid distribution phase, a long terminal disposition phase followed (mean terminal half-life of ∼53 h).

After the rapid distribution phase, a long terminal disposition phase followed (mean terminal half-life 64.1 h).

We have shown previously that the terminal disposition half-life of SN-38, the active metabolite of irinotecan, is much longer than earlier thought.

Sagopilone serum concentrations decreased to <10% peak concentration by 10 h after infusion end, followed by a long terminal disposition phase.

We hypothesised that, because of the poorly defined relationships between pharmacokinetic parameters and pharmacodynamic outcome of CPT-11 treatment (Mathijssen et al, 2001), the prolonged terminal-disposition phase of SN-38 should be taken into consideration in future studies to identify kinetic correlates that would assist in prediction of the dose-limiting myelosuppression.

The terminal-phase disposition rate constant (λz) was estimated by a log linear regression of the terminal monoexponential portion of the observed plasma concentrations.

From the terminal log-linear (disposition) phase, a first order elimination rate constant (λz) was estimated by linear regression and terminal half-life value (t½) was estimated from at least three concentration values using the equation (t½) = ln2 / λz.

For all analytes the AUC was estimated from the start of infusion by the logarithmic-linear trapezoidal rule and extrapolated to infinity using the estimated value of the slope of the terminal logarithmic-linear disposition phase.

A two-compartment model was used to calculate serum pharmacokinetic parameters of AUC (area under the serum concentration curve extrapolated to infinite time), CL (total serum clearance), T1/2α and T1/2β (half-lives of the initial and terminal phases of disposition) for I- and In-ch806.