In this paper we introduce the robust random number generation problem where the goal is to design an abstract tile assembly system (aTAM system) whose terminal assemblies can be split into n partitions such that a resulting assembly of the system lies within each partition with probability 1/n, regardless of the relative concentration assignment of the tile types in the system.
In all models, the accessory helix is proposed to prevent C-terminal assembly of a partially assembled SNARE complex either by inserting into the complex (C ), by binding to the synaptobrevin SNARE motif (D ), or by electrostatic repulsion with both membranes (E ).
We initially proposed that part of this helix might replace part of the synaptobrevin SNARE motif in trans partially assembled SNARE complexes, hindering C-terminal assembly of the complex (Xue et al., 2007; Figure 1C).
Using Bordetella pertussis adenylate cyclase toxin, we solved the structure of an essential C-terminal assembly that caps the RTX domains of RTX family leukotoxins.
We present evidence supporting the notion that the coiled-coil formed by helix D distal to the AB CaM-binding module indirectly favors trans-binding of CaM to Kv7.2, and that CaM binding stabilizes the tetrameric C-terminal assembly.
EdmS has two distinct domains: an N-terminal membrane-anchoring domain and a C-terminal assembly accelerator-like structure, and mutational analysis of edmS revealed that both domains are essential for EDM.
However, based on the fact that HBV core particles specifically bind to the HBV pregenome or genome in vivo, we inferred that the binding specificity to the human genome might be mediated by the C-terminal arginine-rich domain, along with other regulatory regions in the N-terminal assembly domain.
Fibrillar α-synuclein was added to control reaction to assess the unspecific effect of fibrils addition on Ure2p and its N-terminal fragments assembly reactions.
Each TNC subunit consists of an N-terminal tenascin assembly region, 14.5 epidermal growth factor-like (EGF) repeat domains, a variable number of fibronectin type III-like repeats (FN III) and a C-terminal fibrinogen-like domain [ 12].
Lack of CSP-α in photoreceptor terminals impaired assembly of the SNARE complex, which is required for membrane fusion and the development of ribbon synapses, leading to progressive neurodegeneration (Sharma et al., 2011).
