We assume that our models describe the initial phase of differentiation and that the phenotypic compositions of the population do not change significantly during the differentiation process.
However, regulation of the initial phase of differentiation is complex and subject to the influence of multiple factors, such as growth factors, cytokines, and hormones.
These results indicate that the inhibition of adipogenesis by BSO occurs at least in part during the initial phase of differentiation, which represents the mitotic clonal expansion phase required for preadipocyte differentiation.
Our data suggest that during the initial phase of differentiation the Notch signalling cascade is activated.
In the initial phase of osteoblastic differentiation (differentiation of MSCs to osteoblast progenitor cells), Runx2 inhibited differentiation of MSCs to types of cells other than osteoblasts, which required coordinated action between Runx2 and BMP2-induced Smad5 [ 27].
Alternatively they indicate that the two processes of genetic differentiation of their silent archives, sequence divergence (involving single nucleotide changes) and genome plasticity (gene gain, loss and reshuffling) are not necessarily correlated, especially in this initial phase of taxa differentiation.
Our data indicates that a positive expression of c-FLIP characterizes the initial phases of ovarian carcinogenesis, which corresponds to FIGO I stage and differentiation degree G1.
In the initial phases of launching a company, I didn't have to think about differentiation.
During the initial phases of organogenesis somatic cells progress through a series of events referred to as differentiation, competence acquisition, induction and determination [ 20].
A biphasic decline in plasma concentrations was observed with an apparent half-life of initial phase of 1 h and a terminal phase half-life of 7 12 h.
When placed in vitro, Purkinje cells of both ages undergo an initial phase of neurite elongation followed by the development of terminal ramifications.
