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These early glycation products undergo further complex reactions such as rearrangement, dehydration, and condensation to become irreversibly cross-linked, heterogeneous fluorescent derivatives, termed advanced glycation end products (AGEs) (6).
17 18 The effectiveness of screening depends on the identification and removal of colorectal adenomatous polyps with features associated with an increased risk of malignant transformation and early stage malignant disease, together termed "advanced colorectal neoplasia".
It is now well established that early glycation products undergo further progressive modification over time in vivo to the formation of irreversibly cross-linked senescent macroprotein derivatives termed "advanced glycation end products (AGEs)" [ 1- 3].
Under oxidative stress or poor glycemic control, RBCs may undergo posttranslational modifications due to nonenzymatic glycosylation (glycation) reaction, a process that leads to the formation of glycated proteins termed advanced glycation end products (AGEs) [ 46, 47].
Hyperglycemia induces increased glycation of proteins, and they undergo further complex reactions to become irreversibly cross-linked, then termed advanced glycation end products (AGEs).
Some of its ligands form in the presence of hyperglycaemia or oxidant stress and are termed advanced glycation endproducts (AGE).
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