The panel added, however, that long-term studies should be done to confirm its safety.
Larger and long-term studies should be conducted to clarify the impact of FGF-23 elevation among AKI patients.
TWW irrigation is a strategy with many benefits to agricultural land management; however, long-term studies should be implemented to investigate the microbiological characteristics of soil and to assess the feasibility of wastewater reuse for irrigation.
In the future, long-term studies should be pursued to standardize and detail the program, with particular emphasis on studies to confirm the effects of the program in patients with diseases, such as cancer.
A negative impact on the bone graft itself or on remodeling processes in follow-up could not have been shown, but prospective long-term studies should be performed to deliver reliable data on the impact of membrane perforation on graft stability and implant survival.
Thus we propose that similar long-term studies should be undertaken worldwide to assess how frequently VDPVs are present in the environment and the potential global risks posed by aVDPVs and iVDPVs.
Further long-term studies should be conducted with a larger sample size to explore the morbidity and consequences of pressure ulcers and plausible biological mechanisms underlying its development.
Future long-term studies should be conducted to confirm that astaxanthin inhibits the early phase of obesity-related colon tumorigenesis by improving insulin resistance and the imbalance of adipokines in several animal models.
Larger-scale and longer-term studies should be undertaken to focus on the effects of lutein and/or zeaxanthin on early AMD, and more sensitive measurements should be used.
But further in vivo long-term studies should be carried out to provide additional information concerning the mechanisms involved in the stimulation of bone by this new, highly bioactive material before Biosilicate can be used with confidence as a treatment within the clinical setting.
