Therefore, even if no responses were observed, one cannot completely rule out some activity of IM862 in term of prolongation of SD or time to progression, as it has been recently reported for bevacizumab (Yang et al, 2003).
We hypothesise that patients are less prone to accept therapy when the benefits of long-term intervention are presented in terms of prolongation of life (POL) in months compared to the absolute risk reduction (ARR).
By contrast, the combination of cediranib with rapamycin was additive or supra-additive in four of the six models in terms of prolongation of time to event, though tumor regressions were not observed for this combination.
Once again, the benefits were relatively modest in terms of prolongation of median overall survival, but a minority of patients achieved what appeared to be more durable responses.
Despite of only modest objective response rates according to the Response Evaluation Criteria in Solid Tumors (RECIST) [ 44], several studies showed encouraging results in terms of prolongation of the time to progression (TTP), disease stabilization (DS), and survival.
Despite of only modest objective response rates according to the Response Evaluation Criteria in Solid Tumors, several studies showed encouraging results in terms of prolongation of the time to progression, disease stabilization, and survival.
Despite of only modest objective response rates according to the Response Evaluation Criteria in Solid Tumors (RECIST) [ 111], several studies showed encouraging results in terms of prolongation of the time to progression (TTP), disease stabilization (DS), and survival.
Since increased activity of the enzyme or a higher alpha-GPDH/6PGDH ratio are associated with a lower risk of recurrence (Deshpande et al., 1981), it is postulated that the beneficial effects of tamoxifen or prednisolone in terms of prolongation of the relapse free interval might be mediated via alterations in the activity of alpha-GPDH in micrometastases.
The general question chosen for the dialogues was: "What is a life-prolonging treatment?" While the term "life-prolonging treatment" is used in herein, "life-prolonging therapy" and "life-prolongation" were also used in the forums.
The aim of this section is to outline the main features of the Hamilton mechanics realized in terms of prolongations to Lie algebroids (with associated covector, dual and bundles) provided with N-connection structure, defined by a Lagrangian and/or Hamiltonian.
Feasibility of this treatment approach has not been prospectively evaluated in terms of the prolongation of recurrence-free survival time in responding patients.
