Finally, the smoothness term enforces the constraint that neighboring pixels of similar intensities should be assigned the same label [33], which is defined as (16).
To see that the first term enforces the third property, observe that this expression is a sum of components of the form Xij dest,i - cj 2.
In (5), the second and third terms are seen as the ℓ2 regularization functions, the fourth term enforces the distance between different common bases to be small, and the fifth term enforces the distance between different individual bases to be large.
To see that the first term enforces the fourth property, note that this expression is a sum of components of the form Xij (dT,ist,i - cj 2 and Xij (dS,ist,i - cj 2.The constants β1, β2, β3 can be used to balance the relative importance of the four properties.
In brief, MODELLER generates the 3D atomic coordinates of the target sequences by satisfying spatial restraints, obtained from the templates, and by CHARMM 23 energy terms enforcing proper stereochemistry.
For CAG elements, the strain density function in the above equation is replaced by U d (F AN (ξ, q ), t ) while the mixed terms enforcing the weak equivalence of F AN and F h do not contribute to the action and can be neglected.
Our protocol will allow for a deeper understanding of nicotine addiction in the setting of long-term enforced abstinence and provide for future informed interventions prior to release.
The l1 penalty term enforces sparsity of the elastic net estimator, whereas the l2 penalty term ensures democracy among groups of correlated variables.
The confidence term enforces to fill hole with large support set of known pixels first, while the data term ensures the continuous propagation of linear structure into hole regions.
This coupling term enforces a certain degree of synchronization of the slow dynamics allowing for a more objective assessment of model performance.
