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To prevent aneuploidy, the cell generates a 'wait-anaphase' signal known as the SAC that inhibits anaphase onset until all kinetochores achieve biorientation, and tension is established between sister kinetochores[9].
In wild-type cells at metaphase I, tension is established though crossovers between homologous chromosomes, cohesion between sister chromatids, and amphitelic attachment of homologs.
To prevent aneuploidy, the cell generates a 'wait-anaphase' signal known as the spindle assembly checkpoint (SAC) that inhibits anaphase onset until all KTs achieve biorientation, and tension is established between sister KTs (Musacchio and Salmon, 2007).
Similar(57)
With the application of the average failure strain, a bilinear damage evolution model for high strength hull steel in biaxial tension stress is established.
The actual stress strain relationships in both compression and tension were established by performing a series of compression and tension tests on PVA micro-fibers reinforced concrete specimens.
The determination of surface tension was established as the measurement of the force needed to pull a metal plate out of the interface.
For the general choice of phase variables, the unisolvent property of the coefficient matrix involved in the N-phase models based on the pairwise surface tensions is established.
As a result, an interfacial tension gradient is established to counteract the thinning and ensure the stability of the emulsion (Kocherginsky et al. 2003).
How, then, is kinetochore microtubule attachment stabilized once bi-orientation is established and tension is applied (Fig 2)?
If bi-orientation is established and tension is applied, turnover no longer occurs and kinetochore microtubule attachment is stabilized.
How the kinetochore microtubule interaction is stabilized when bi-orientation is established and tension is applied is still a matter of debate (Sidebar A).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com