Exact(2)
Here we describe the validation of a method that combines the ability to screen tens of compounds a day, with direct assessment of channel function.
Although truly high throughput screening would be impossible in this system, it allows us to test tens of compounds over a period of a month, in comparison to several years for testing the same number of compounds in vivo.
Similar(58)
Martin plans to screen hundreds of thousands of compounds in search of an effective anti-proteasome drug.
The multiplexed nature of this approach allows rapid in vivo analysis of hundreds to thousands of compounds.
The current process starts with testing thousands of compounds which will in the end, produce a single drug.
We don't exactly know why this little bean has such big benefits, since coffee has hundreds of compounds.
The team used a technique called high-throughput screening, which rapidly allows researchers to examine hundreds of compounds.
Strittmatter and research scientist Erik Gunther screened tens of thousands of compounds looking for molecules that might interfere with the damaging prion protein interaction with amyloid beta.
To get such a detailed profile, the research team used high-performance liquid chromatography (HPLC), which separates thousands of compounds in a sample.
Because companies typically screen hundreds of thousands of compounds - and occasionally a million of them - at a time, an automated and easy-to-read assay would save time and money.
The standard practice for identifying chemicals that might be effective in targeting particular diseases involves testing hundreds of thousands of compounds, and there is no cost-effective way to test all of them against all potential disease mechanisms.
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