Their tendency was down-regulation, except for those predicted to be involved in energy, nucleotide and amino acids metabolic pathways which were generally found to be up-regulated (Figure 1A).
However, hsa-miR-140 showed a tendency to be down regulated in OA and hsa-miR-146 showed a tendency to be up regulated in this pathology.
Structural protein encoding mRNAs showed a marked tendency to be down regulated, as seen with the collagens and the myosins, β-actin, and troponin (Table 4).
Analysis of expression patterns by agglomerative hierarchical clustering showed a high number of up-regulated genes in the last time point evaluated (2 h) while an opposite tendency was observed for down-regulated genes which were more responsive in the first time point (10 min).
A significant down-regulation tendency was consistent with its proper negative role at BK stage.
"Not with the physicality, but maybe with fighting, the tendency is it slows down in the second half of the season," said Brandon Prust, whose 19 fights are tied for the N.H.L. lead.
British speech, especially RP, usually varies much less within a sentence than American English, and the general tendency is to go down slightly towards the end of a phrase.
A similar tendency was seen in SCCs.
This tendency was conserved in each individual.
There's pots of money out there, and the slight unwillingness may be down to the tendency of literary folk to denounce the sources of prize funds, once you give them dinner and a microphone to speak into.
Sir Rembrandt, a well-beaten sixth in the same race, was yesterday ruled out of the Gold Cup by trainer Robert Alner, who believes the eight-year-old's tendency to jump to his right is down to a muscle problem.
