The presence of heterotopias only in one control subject is evidence of a strong tendency for focal developmental changes of cerebellar microarchitecture that were present in 61% of the autistic subjects.
The study of the developmental basis for phenotypic variability addresses a higher level of abstraction in that it deals with the tendency of developmental systems to change, amplify, or reduce the expression of genetic variation at the phenotypic level.
Recent studies revealed that lncRNAs tend to share some properties such as a tendency for location next to developmental regulators, an enrichment of tissue-specific expression patterns, and a certain degree of evolutionary conservation in functional domain-containing sequences and predicted secondary structure [ 17– 17].
There was a tendency for haplotype I to show shorter developmental time and higher viability compared to the other haplotypes (Fig. 2, Additional file 1: Table S1), but this trend was not significant.
Canalization buffers developmental pathways against the tendency for both new allelic variants and environmentally-induced noise to generate suboptimal phenotypes, and thereby ensures the reliability of vital mechanisms such as cognition, glucose metabolism or immune response [ 4].
(D.I.R. stands for developmental, individual differences, relationship-based approach).
Arnold Gesel, in the forties, wrote that kids work their way up a "developmental spiral," and pushed mothers to be on the lookout for developmental lags.
Memorial donations may be made to Matheny School and Hospital for developmental disabilities, Attn Faye Mackey, Main Street, Peapack, NJ 07977.
Chickens became a favorite animal for developmental biologists who studied limbs.
Nor, for developmental reasons, should 16- or 17-year-olds be subject to the death penalty.
