Otherwise, some investigators may be tempted to estimate the ratio of benefit to harms in the trial of high-risk subjects and extrapolate the ratio to average risk subjects.
Although it is tempting to try and estimate selection against hybridization in the contact zone studied here, because the hybrid zone is dynamic and/or asymmetric, we cannot sensibly do so under a standard tension zone model, which assumes a symmetric, static hybrid zone.
Should the situation arise in which the postulated ICC suggests that it is not possible to detect the required difference (at pre-specified power), it might be tempting to lower the estimated ICC.
Firstly, the sample sizes are so large that the MSE is small in absolute terms for the UMVCUE also, and when the expected error is small it is tempting to take the estimate at face value.
Although it is tempting to interpret the estimate for CHD seen in non-smoking ε4 carriers as suggestive that this subgroup does not have an elevated risk of CHD compared to non-ε4 carriers (since the 95%CI includes the null), this is likely due to reduced power within strata of subgroups, and the salient feature is the lack of evidence for interaction between APOE genotype and smoking status.
It is tempting to produce a single estimate of the treatment effect of probiotics.
Since adding clusters entails more parameters, it is tempting to use the Akaike Information Criterion AICC) or the Bayesian Information Criterion BICC) to estimate the number of cluster in the Poissom model [ 64, 65].
It is tempting to believe that cumulative stress can be estimated just like other delayed effects of heat exposure effects, e.g. by distributed lag models.
Also, although it is tempting to interpret the Trasande results as estimates of benefits, this would be wrong.
Methods for estimating τ have been suggested above and it is tempting to consider using weights a i = 1 / (σ i 2 + τ ^ 2 ), where τ ^ 2 is some estimate of τ.
