Evasion of apoptosis and temporary inhibition in proliferation are mechanisms adopted in drug resistance [ 39].
It seems that expression and cleavage of EpCAM is associated with a temporary need for proliferation of tumor cells [ 48], which might be essentially reduced when tumor cells enter the bloodstream.
The scaffold should act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent tissue ingrowth.
In order to restore the function or regenerate tissue, it is necessary that a scaffold must act as a temporary matrix for cell proliferation and ECM deposition, with subsequent ingrowth until the tissues are totally restored or regenerated.
Biodegradable scaffold matrixes form the basis of any in vitro tissue engineering approach by acting as a temporary matrix for cell proliferation and extracellular matrix deposition until the scaffold is replaced by neo-tissue.
A scaffold is required, until the tissue is entirely regenerated or restored, to act as a temporary ingrowth template for cell proliferation and extracellular matrix (ECM) deposition.
To allow cell attachment and proliferation an adequate temporary scaffold must be provided, while synthesis of extra-cellular matrix proteins and tissue re-organisation take place.
As long as the loss of inhibition of cell growth is temporary, the capacity for enhanced cell proliferation when necessary has obvious advantages.
Think, for instance, of the recent proliferation of art fairs, those temporary art malls where sensory overload competes with sensory deprivation because everything sort of looks the same.
Most tissue engineering (TE) strategies for creating functional replacement tissues or organs rely on the application of temporary three-dimensional scaffolds to guide the proliferation and spread of seeded cells in vitro and in vivo.
