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In conclusion, both their expression and the genetic manipulations described here point to a central role of Hr39 and Eip75B in the temporal repression of the CRMs identified in this study.
Comparing jai1-1 and WT stamens in terms of gene expression and metabolite accumulation, this study revealed that jasmonates regulate pollen nutrition and thereby pollen development, but most obviously they are an important regulator of the proper timing of stamen dehiscence via a temporal repression of ET biosynthesis and action.
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Inappropriate temporal and spatial repression of MHC genes by overexpressed MeCP2 might induce defects in neuronal functions similar to those observed in β2m/TAP1 deficient mice [41].
Furthermore, Abdominal-B controls by repression the temporal onset of neuropeptide expression in a subset of CCAP-efferent neurons, and a peak of ecdysone hormone at the end of larval life counteracts this repression.
Using hierarchical clustering, 11 different expression profile clusters were partitioned on the basis of differential sample type and temporal stage-specific activation or repression.
Temporal delays between activation and repression are built into the circadian loops that allow the generation of RNA and protein-level oscillations with a 24-hr periodicity.
This indicates that, while the function of these three genes is partially redundant, with normal expression of the three genes the temporal window of CCA1/ LHY repression is extended.
Development of the vertebrate retina requires complex temporal orchestration of transcriptional activation and repression.
The ftn mRNA expression levels were down-regulated 4- to 20-fold in the SO2426 null mutant across the entire temporal range, with the peak in repression occurring at the 180-min time point (Table 1).
Such a basal activity, which was not scored in these latter cells, may reflect the rather generic nature of the activating signals, the general mechanism underlying temporal colinearity thus relying on de-repression.
This paper reveals a temporal uncoupling between CpG-island methylation and repression of transcription during early Xenopus laevis development.
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