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A transcriptional-regulatory system is based on the presence of transcription factor binding sites of genes which are responsible for receiving temporal regulatory input signals, integrating these signals and producing output in terms of gene expression [7].
However, traditional network inference approaches could not identify such temporal regulatory relationship due to limited time points available.
Together with our previous studies (Minguillon et al., 2012; Nishimoto et al., 2014), we reveal the spatial and temporal regulatory mechanisms of Tbx5 expression.
The temporal regulatory patterns of the DosR regulon observed in vitro has provided some clues as to the spatial regulatory patterns of the DosR regulon in vivo.
In this work, we carried out a microarray-based temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization using GAGE method.
This study reveals a pathogenic mechanism wherein disease mutations uncouple Rab7 from normal spatial and temporal regulatory restraints resulting in toxic misregulation of Rab7 activity.
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In these contexts, a truly biologically meaningful annotation of the reference genomes of rice that could facilitate a holistic understanding of the nature of allelic and epiallelic variation for phenotypes of interest must include information on the critical cis-elements and trans-acting factors that define the spatio-temporal regulatory properties of each gene.
Spatio-temporal regulatory dynamics of SHY2[ 94] and CCA1[ 96] 96] have been reported earlier.
Regardless, the title of the article and some language, especially in the abstract, seem to imply direct contribution of TEs to the co-temporal regulatory innovations.
The 'grammatical organization' of motifs within CRMs that encode complex spatio-temporal regulatory information can further complicate motif search compared with similar tasks in simpler organisms such as yeast (Frith et al., 2002).
Maier and colleagues [ 25] proposed that this feature could either be a prerequisite for the spatio-temporal regulatory needs of embryophytes and an adaption to the peculiar requirements of a terrestrial life style or it might be the mere result of the specifics of the plant organelle genetic systems in interaction with the nuclear genome (transgenomic suppression of point mutations).
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