Only when dephosphorylated, Cdc2 forms a complex with cyclin B1 and allows dividing cells to enter mitosis from G2 phase, thus maintaining the highly regulated temporal order of cell cycle progression.
Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control.
The parietal lobe processes sensory information and houses our language abilities, and the temporal lobe regulates emotion, hearing, language, and learning, which could explain why language outcomes are poorer in children with abnormalities in these regions.
One possibility is that a cell intrinsic program in Ngn3+ progenitor cells regulates the temporal order of generation of differentiated endocrine cell types.
DNA is replicated in a defined temporal order that is developmentally regulated and constitutes a unique and stable fingerprint of a given cell type.
Previous gene regulation studies of 22-kDa α-zeins showed that their tissue specificity and temporal expression are regulated epigenetically.
This tightly regulated temporal progression is controlled by the sequential activation of CDKs and their subunits, cyclins that phosphorylate the Rb protein.
This is the case of cornification of the skin, a process discussed and reviewed by Candi et al. Cornification of the skin is a highly regulated temporal and spatial process of terminal differentiation of keratinocytes in which the resultant dead cells form a barrier in the uppermost layer of the skin.
Although we ordinarily collate the reviews into a single narrative, the reviewers felt that you would benefit by a full disclosure of their comments: Reviewer #1: This manuscript addresses the mechanisms by which P-granules (maternal mRNA-protein assemblies in C. elegans) assemble and disassemble in a temporal and spatially regulated manner.
Although it is possible to reconstitute Jmjd3−/− macrophages with wt and catalytically inactive Jmjd3 using viral vectors (data not shown), we have been unable until now to reproduce the physiological, highly regulated temporal profile of its expression; moreover, levels of expression achieved this way are much higher than the endogenous ones, thus making such experiments not reliable.
