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Importantly, our studies identify the rare temporal pathways that result in induced pluripotent cells.
For example, it has been shown after postnatal excitotoxicity in the brain that caspase-3 in glial cells (mainly astrocytes and oligodendrocytes) works via different spatial and temporal pathways than in neurons.
For example, Figure 2a plots the temporal pathways of individuals allocated to the low class in early childhood and similarly, Figure 2b plots the pathways for those starting in the moderate class.
Longitudinal data analyses can help us to better uncover the temporal pathways of children's transition through the education system and how these transitions may be affected by conditions within households and communities.
These results may also address some inconsistencies in the literature, where associations have been found between face recognition and locally defined ventral temporal pathways but not with long-range ILF (Tavor et al., 2014; Gomez et al., 2015).
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Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
We mapped the spatial and temporal pathway for the assembly of more than a dozen proteins in the equatorial contractile ring of actin filaments and myosin-II and are investigating how a formin protein mediates actin assembly and how cells trigger constriction of the ring at the end of mitosis.
"It certainly doesn't geographically leap out at me and say it's following the geographic and temporal pathway than HIV did," Worobey says.
At data analysis level, we developed a novel temporal pathway analysis procedure.
To our knowledge, these methods do not infer temporal pathway level changes without reference patterns.
However, the spectrum of temporal pathway deregulation has rarely been studied using a systematic framework.
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