Development of the vertebrate retina requires complex temporal orchestration of transcriptional activation and repression.
Ma, D., Panda, S. & Lin, J. D. Temporal orchestration of circadian autophagy rhythm by C/EBPbeta.
Instead, sprout formation and the subsequent patterning may be the result of a complex, temporal orchestration of multiple extracellular VEGF fractions, receptor signaling states, and cell types.
Therefore, the discovery and characterization of additional motifs promises to reveal further levels of circadian regulatory complexity and facilitate a system-wide appreciation of the principles that underpin the temporal orchestration of gene expression.
- Although the spatial and temporal orchestration of early embryogenesis is missing in cell culture systems, many of the regulatory machineries affecting embryonic development also regulate ESC differentiation in vitro.
Palate development is a complex and incompletely understood process that requires a fine spatial and temporal orchestration of molecular and tissue interactions during embryogenesis that enable outgrowth, elevation, reorientation, adhesion and fusion of palatal shelves (Gritli-Linde, 2007; Iwata et al., 2011; Yu and Ornitz, 2011).
Adhesion based spatio-temporal orchestration of actin-polymerization-driven invasive structures [ 40] is a feature of many physiological and pathological events.
Although the spatio-temporal orchestration and kinetics of ATG protein recruitment has been analyzed in great detail, it is still completely unknown as to which molecular events trigger the initial recruitment of ATG13 to the omegasome and what leads to its disappearance at later stages of autophagosome maturation.
An alternative is to share responsibility for orchestration between the teacher, the students, and the technology.
Conceptually, a dual role for pRb as a regulator of both cell cycle progression and adherens junction assembly could be of central importance in the orchestration between cell proliferation and cell adhesion, an orchestration that may be pivotal for tissue morphogenesis.
