To add to the complexity, temporal fluctuations in lifespan of particular lines were observed.
To tease apart the role of spatial and temporal effects in the variable lifespan blood vessel model, we developed a "fixed lifespan blood vessel" model in which we controlled more precisely spatial and temporal dynamics.
Unexpectedly, we find that sequentially occurring fate-switch decisions are temporally coupled, and onset of Tgfβ signaling appears thereby to impact on the overall lifespan of the temporal lineage.
Most of the existing studies in temporal data mining consider only lifespan of items to find general temporal association rules.
Webster, M. J., Herman, M. M., Kleinman, J. E. & Shannon Weickert, C. BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan.
More importantly, we found that the effects of rhizome severing on root lifespan displayed both temporal and spatial features such that lifespan for roots born in different seasons and distributed in different soil layers responded to rhizome severing differently.
Using this simplified model, we can control the degree of spatial heterogeneity by controlling the number of blood vessels, and the degree of temporal heterogeneity by varying the lifespan of a blood vessel (or the density of cells that cause occlusion to in the variable lifespan blood vessel model).
First, the growth retardation hypothesis is based on the statistic and descriptive correlations between temporal lengths of growth and lifespan, whereas this model is based on the fundamental mechanisms of energy tradeoffs between growth and maintenance.
Decreasing blood vessel numbers and lifespan (increasing spatial and temporal heterogeneity) selected for increased cell migration and number of emigrating cells (Figure 3; linear regressions P<0.001).
The increase in root lifespan exhibited spatial and temporal characteristics such that it increased lifespan for roots distributed in the top two soil layers and for roots born in summer and spring, but it had no effect on lifespan of roots in the deep soil layer and born in autumn.
