As temporal changes of guidelines, percentages of ART initiation significantly increased in newly ART eligible people and did not decrease in individuals with very low CD4 counts.
Therefore, the temporal pattern provided in the guidelines appears inadequate and not applicable to all patients, as said above.
Based on major findings from time ecology, we suggest guidelines to acknowledge temporal diversity that could contribute to developing solutions with a long-term contribution to sustainability.
Three periods following the temporal change of ART eligibility guidelines were defined (Period 1: until April 2010; Period 2: April 2010 - July 2011; Period 3: from August 2011).
The objective of this study was to evaluate the temporal relationship between clinical practice guideline development and subsequent research performed, with the goal of providing more data on areas of sparse evidence that serve to underlie guideline recommendations.
We thus aimed to describe ART initiation percentages in a large HIV programme in rural KwaZulu-Natal, South Africa, according to the temporal changes of national ART eligibility guidelines from 2007 to 2012.
We also stratified the results by year of study publication in order to capture any temporal change since the publication of the STARD and QUADAS guidelines.
Reported inverse modeling methodology is robust to the presence of errors in the offset of the pressure temporal transients, specifically when compared to current clinical guidelines, as shown in Fig. 8.
The system should be capable of providing instant automated reports to each user on demand and of containing the information needed, e.g., molecular typing information, spatial and temporal data, and related information, such as treatment guidelines.
We identified four types of discrepancies between the local and cloud-based services that likely contributed to the discordance: 1) terminology misalignment, 2) local practice variation, 3) temporal windows, and 4) use of exclusions in guidelines implementation.
