Careful investigation of the temporal effects of killing after TCR engagement may reveal differences between Fas and Bim effectiveness.
This metabolite stimulated cortisol secretion and expression of steroid hydroxylase with a temporal pattern, potency, and effectiveness similar to the parent ESCA (Figure 5).
Accordingly, putative metabolites of 8CPT-2'-OMe-cAMP, including 8CPT-2'-OMe-5'AMP, 8CPT-2'-OMe-adenosine, and 8CPT-adenine all induced cortisol synthesis and steroid hydroxylase mRNA expression with a temporal pattern, potency, and effectiveness similar to the parent compound.
8CPT-Ade also induced a delayed increase in both cortisol synthesis and expression of steroid hydroxylase mRNA with a temporal pattern, potency, and effectiveness similar to each of the previously described putative metabolites (Figure 6C, D).
Indeed, BMP4 is a known potent mesoderm morphogen in hESC [39], with a brief temporal window of effectiveness for mesendoderm induction (d1 d2) [40].
The strength of our study is that we investigated temporal trends in screening effectiveness over time between 1975 and 2008.
Figure 8 illustrates another example for the effectiveness of temporal filtering.
Efficiency includes parsimony (conceptual efficiency), speed (temporal efficiency), and cost effectiveness (financial efficiency).
Second, the effects of time can be included in the statistical model, hence controlling for temporal changes in the effectiveness of the program [ 23, 24].
Analysis of stepped wedge trials can adjust for possible temporal trends in the effectiveness of the intervention, and the design reduces the impact of intra-cluster correlations on power because each group acts as its own control [ 54].
