Most early studies into multiple sclerosis focused on the most striking feature of the disease, that of focal white matter demyelination; typically associating disease severity with the spatio-temporal dissemination of sclerotic CNS lesions (Carswell, 1838; Charcot, 1868; McDonald et al., 2001; Polman et al., 2005).
An unexpected geographically and temporal widespread dissemination of some clones was demonstrated.
Because of an inadequate national surveillance system, temporal emergence and dissemination of the strain in the United States is uncertain.
Therefore, the objective of the present study was to identify the characteristics of the spatial-temporal pattern of dissemination in the first dengue epidemic that occurred in a large Brazilian city.
From the end-users' perspective, optimal conversion of huge files of spatio-temporal data for further dissemination, accuracy of conversion, organization of content and security have a key role for effective geo-collaboration.
Specifically, the two issues need to be addressed in this problem are maintenance of temporal data freshness and timely dissemination of data.
Subsequently, we establish a probabilistic model to theoretically analyze the tradeoff between timely temporal data update and requested data dissemination sharing a common communication resource, which provides a deeper insight of the proposed RTIS.
A limitation of this analysis is that we only consider temporal changes in removal, though information dissemination and public concern almost certainly led to a decline in transmission (β0) too [15].
To start filling this gap, our study adopted a User-Centered Design approach and first explored the user requirements of environmental researchers working on distributed research projects for collaborative dissemination, exchange and work with spatio-temporal data.
These data suggest temporal improvements in blood pressure control in diabetes that may reflect broad dissemination of tighter blood pressure control targets and improving medication access.
24 To investigate the dissemination of clonal complexes through the regional healthcare network we considered temporal associations between strain prevalence density in ICU, hospital and community and among those colonised with MRSA at admission.
