This case included information on temporal association, discontinuation and rechallenge, but lacked information on dosage, previous similar events and objective evidence.
When designing a structured or semistructured interview form, information on dosage, previous similar events and objective evidence should be requested, in addition to the essential information regarding temporal association and discontinuation.
Furthermore, two of the clusters (Cluster ID 20, 24) were identified as being longer in duration by the temporal scan statistic; therefore, premature discontinuation of infection control measures by IPC personnel may have occurred.
We defined the sequential progression of therapies based on their temporal relationships using the dates of initiation and discontinuation provided in the administrative claims.
While a spontaneous remission or a placebo effect cannot be completely ruled out in the present case, different criteria sustain topiramate efficacy: the previous case reports, the temporal correlation with the topiramate administration, the relapse after discontinuation and the responding after resumption of the treatment, and the absence of any contributing life event.
Secondary objectives were to explore, in a managed care population, the rate of discontinuation of PEG-IFN-alfa/ribavirin therapy and the temporal pattern of the costs of these TECs.
The cross-sectional nature limits the ability to explore the temporal association between statins and mammographic density in terms of initiation and discontinuation.
A crucial element in establishing a diagnosis of DILI is the temporal relationship between drug exposure to development of liver injury and resolution following discontinuation of the drug.
In this manuscript, we evaluate the immediate and long-term implications of AED reduction, AED discontinuation, or continuation of preoperative AED regimen in patients who underwent temporal lobe epilepsy (TLE) surgery.
Among 4 patients who could stop treatment with temporal resolution of cough, cough recurred in 3 patients, 1 week to 8 months after the discontinuation.
In view of the previously reported association of bortezomib with thrombotic microangiopathy, the temporal association of the clinical picture with the initiation of carfilzomib, and the partial resolution of symptoms after discontinuation of the drug, we conclude that carfilzomib may have precipitated a case of clinically evident renal thrombotic microangiopathy in our patient.
