Because gamma processes are well suited for modelling the temporal variability of deterioration, they have proven to be useful in determining optimal inspection and maintenance decisions.
To investigate the temporal relationship between microglial deterioration and neurofibrillary degeneration, we took advantage of the predictability of the spread of tau pathology inherent to Braak staging, namely, that neurodegeneration proceeds predictably from the allocortex (entorhinal and hippocampal areas) to the isocortex [ 4].
In older humans, deterioration of medial temporal lobe dependent memory function occurs in a large segment of the population and confers significant risk for development of Alzheimer disease.
Frontotemporal dementia is one of the most frequent presenile onset dementias [ 19], with neuronal degeneration in the frontal and temporal lobes causing a progressive deterioration of behavior, personality and/or language [ 24].
Based on this work, risk assessment may be applied at more than one point in time in order to observe temporal trends in recovery or deterioration in future CAP research and clinical practice.
Our findings show that mechanical obstruction of circulation in the circle of Haller and Zinn causes segmental anoxia in the temporal arcuate region and progressive deterioration corresponding to that seen in glaucoma.
A temporal pattern of white matter functional deterioration and recovery can also be established to study mechanisms of demyelination-induced white matter injury and repair.
Longitudinal investigation of the temporal ordering of depression and QoL deterioration in HIV infected women with early gender-based violence will be key to elucidating these relationships.
Conversely, deterioration is quicker than temporal variant AD, perhaps owing to greater cognitive reserve in these individuals (consistent with their older ages of onset), the more focal mesiotemporal distribution of pathology that tends to spare cortical areas, or some combination of both.
The pathogenesis and behavioral effects of normal pressure hydrocephalus (NPH) are not fully understood, and the temporal relationship between radiological changes and neurological deterioration is unknown.
