TDP-43 is a multifunctional RNA-binding protein found to be a major protein component of intracellular inclusions found in neurodegenerative disorders such as Fronto Temporal Lobar Degeneration, Amyotrophic Lateral Sclerosis, and Alzheimer Disease.
Since reported cases of BIBD represent a spectrum ranging from pure MND to pure FTD, categorizing all BIBD cases as a subtype of FTLD-FUS does not seem to reflect the clinical and pathologic features of BIBD, particularly given that clinical signs of frontotemporal dysfunction may not be seen and frontal or temporal lobe degeneration may be absent.
Speech-based features are investigated in [5] to detect fronto-temporal lobar degeneration with promising results.
They include Alzheimer's disease (AD), fronto-temporal lobar degeneration (FTLD-Tau), Pick's disease, progressive supranuclear palsy and corticobasal degeneration.
FTLD studies were considered if they consisted of subjects with Fronto-Temporal Lobar Degeneration or related diagnoses, such as Semantic Dementia.
The following Boolean phrase was used: {([Magnetic Resonance Imaging] OR [MRI]) AND ([Schizophrenia] OR [schizo*] OR [FTLD] OR [Fronto-Temporal Lobar Degeneration) AND ([Voxel] OR [VBM])}.
In this study, we investigate whether there is overlap in the distribution of brain changes in First Episode Schizophrenia (FES) and Fronto-Temporal Lobar Degeneration (FTLD).
There is a significant overlap in the distribution of structural brain changes in First Episode Schizophrenia and Fronto-Temporal Lobar Degeneration.
We recently used support vector machines (SVMs) to separate sporadic Alzheimer's disease from normal ageing and from fronto-temporal lobar degeneration (FTLD).
FUS and EWS are identified in translocation generated cancer fusion proteins and involved in the human neurological diseases amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
