The Fors group is pioneering this approach, which gives spatial and temporal control over the polymer.
Temporal control over synapse development and synapse elimination further ensures the specificity of connections in the nervous system.
Microfluidic devices provide precise spatial and temporal control over cell microenvironment.
Dynamic hydrogels have emerged as an important class of biomaterials for temporal control over growth factor delivery.
Here we report on a strategy to achieve temporal control over nanoparticle release from biomaterials using cell-secreted proteases.
Our results demonstrate the importance of temporal control over signaling in promoting vascular growth, vessel maturation and vascular remodeling.
In order to have strict temporal control over ERK activity, we employed PD0325901 (PD) and U0126 (U0), two potent but structurally independent inhibitors of the ERK-activating kinase (MEK 22,23 (Fig. 2c, d, Supplementary Fig. 1a, b).
Our findings demonstrate that site-specific delivery of inducible and tunable transgenes confers spatial and temporal control over both CDM scaffold remodeling and neotissue composition.
Additionally, photo reactions add spatial and temporal control over reactions, which gives rise to a large number of applications that would otherwise be inaccessible.
One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels' properties and functions.
There are several advantages to this approach over global knockout mice, including normal mouse development and temporal control over when cell depletion occurs.
