Combretastatin A-4 (CA-4) is a well-studied and attractive molecular template to develop new antimitotics.
The protease inhibitors have shown different levels of inhibition and may thus provide template to develop selective and potent drugs against these devastating arboviruses.
These comprehensive structure activity-relationship (SAR) studies demonstrate the application of a 2,4-disubstituted quinazoline ring as a suitable template to develop multi-targeting agents to treat AD.
Collective efforts toward further optimization of this novel tricyclic template to develop better porcupine inhibitors will be subsequently undertaken and reported in due course.
We have used a near-infrared fluorescent protein iRFP engineered from a bacterial phytochrome as the template to develop an in vivo split fluorescence complementation probe.
Appendix 1 outlines a draft CML computational chemistrydictionary for molecular orbitals, and shows a formatted example that can beused as a template to develop a molecular orbital convention in the future.
Furthermore, molecular modeling studies indicate that a central pyrimidine ring serves as a suitable template to develop dual inhibitors of cholinesterase and AChE-induced Aβ aggregation thereby targeting multiple pathological routes in AD.
Should the clinical validation of this drug ranking system demonstrate that it is reliable, the TTD could be utilized as a template to develop similar repositories dedicated to any tumor and more generally to any disease.
Since both NDM-1 and 1ko3 belong to a same enzyme family with the same action mechanism, and their sequence identity is higher than 40%, it is quite reasonable to use the crystal structure of 1ko3 [40] as a template to develop the 3D structure of NDM-1 via homology modeling.
