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"They want to create templates for design, so that the process of building out a WeWork becomes more standardized and more efficient," said Fano.
The results show the utility of considering the PtN4 chemotype for selective reactions with peptides and templates for design of specific protein inhibitors.
The structures serve as templates for design of inhibitors that could be used to test tRNA m1A58 MTase's impact on retroviral priming and transcription.
Recently solved crystal structures of norovirus bound to HBGA have provided a structural basis for identification of potential anti-norovirus drugs and subsequently performed in silico and in vitro drug screens have identified compounds that block norovirus binding and may thereby serve as structural templates for design of therapeutic norovirus inhibitors.
Using high-throughput sequencing, we identified several highly abundant CDR3s, germline-like as well as somatically mutated V genes in the VH/VL repertoires of the patient which may provide antibody intermediates corresponding to known bnAbs as templates for design of novel HIV-1 vaccine immunogens.
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The newly synthesized compounds may serve as structural templates for designing and developing novel tyrosinase inhibitors.
Taken as a whole, present data emphasise the suitability of bis-benzamidines as templates for designing brain protective compounds.
The potent, endogenous complement regulators have become of increasing interest as templates for designing and developing new therapeutics.
Antimicrobial peptides (AMPs), important effector molecules of the innate immune system, also provide templates for designing novel antibiotics.
Our results suggest that these drugs and another two HIV inhibitors (PNU and UC2) could be used as templates for designing SARS-CoV proteinase inhibitors.
These studies reveal the mechanism of action of TLQP-21 and provide molecular templates for designing agonists and antagonists to modulate C3aR1 functions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com