The authors then develop a simple lattice model in which a site can contain up to 3 molecules, templating can occur when exactly 2 monomers exist in a site and diffusion between adjacent sites is allowed.
These template switches can occur at small regions of DNA sequence homology, such as 5 bp.
His group showed that pairs of such inter-chromosomal template switching events can occur between ectopic (non-allelic) homologous sequences as often as once every 100 repair events.
A second hypothesis may be related to the formation of safety templates and gender differences that can occur in this formation.
This suggests that the transient suppression of C-NHEJ by SCR7 skewed DSB repair to the alt-NHEJ and HDR pathways, and that in the presence of excessive amounts of donor template (ssODN), homology-driven repair can occur at a higher frequency.
It was proposed that when the replication fork stalls, e.g. due to single-strand breaks or single nucleotide deletions, repeated template switching to nearby genomic regions can occur, leading to apparent deletions when parts of the template are skipped, and to duplications when the replication machinery "jumps back".
Based on the coordination ability of the hydroxyl groups, the mineralization of the cations can occur on the template to form a layer of SiO2 without additional surface modification.
Errors in template choice during the reverse transcription can occur anywhere along the sequence.
Our insights into the molecular mechanism of remodeling the nuclear envelope for viral nuclear egress provide a molecular template by which nucleo-cytoplasmic transport can occur.
11 Pre-activated nucleotides were also used to demonstrate that copying of a given template sequence into a complementary strand can occur without enzymes, mostly in the form of enzyme-free primer extension.
