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We employed the extracellular domain (PDBID: 11GR) of the insulin-like growth factor-1 receptor (IGF-1R) as the template to simulate and optimize the spatial structures of the three domains in the extracellular domain of the insulin receptor, which includes 468 residues.
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To demonstrate the performance of TEMPI, we generated a template PPI network and GOBPs to simulate characteristics of real yeast PPI networks and then sampled the synthetic TDN model from the template PPI network for which temporal transitions of (i) network structures and (ii) differentially regulated GOBPs associated with the TDN model are known.
Even when all templates sharing >10%% sequence identity with the target were removed (to simulate the lack of similar templates that frequently occur in real world simulations), reasonable predictions for the experimental protein structures were still possible with the average ligand similarity of 0.40 and MCC of 0.28.
In particular, we perform a first attempt to simulate an all sky template of polarised emission from thermal dust.
Through C++ meta-template programming a single code can be used to simulate one-, twor, or three-dimensional systems with no loss of performance.
The 30 Hz template waveform we used the most frequently in our experiments can be considered as a way to simulate a moderate intensity synaptic input, but we did not aim to simulate strong synaptic bombardment that is characteristic of highly active circuits in the awake brain [7].
String instruments are particularly difficult to simulate.
He wanted to simulate a piazza.
Johnson would not struggle to simulate hostility to the EU.
The best way to display this was to simulate masturbation.
Algosurg has built algorithms to simulate surgeries.
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