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::template apply<output_types, input_types>::value }; }; Listing Listing 32 AllowConnectionImpl template structure code partially presents the implementation of AllowConnectionImpl template structure that registers the result of connecting two filters into the enumeration variable value.
The conserved nature of the AprA structure was reflected in the low main chain atom RMS deviations from the template structure that ranged between 0.66 Å (uncultured SRB fosws7f8) and 1.20 Å (O.
Those template-based methods search for the occurrence of a predefined template structure that consists of active-site residue atoms, within target protein structures.
The high quality of MEDELLER's core models is achieved by reliably selecting parts of the template structure that are similar to the correct target coordinates.
Such template-based methods such as TESS (Wallace et al., 1997) are local structure searching (LSS) algorithms, which search for the occurrence of a predefined template structure that comprises active-site residue atoms, from unknown protein structures.
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This established method of superimposing GPCR structures [35] allowed us to quickly generate superimposed co-ordinates of the template structures that could then be used to improve a multiple sequence alignment (MSA).
We too have provided the information if the most druggable pockets of the ORF have highly conserved residues in the Pfam families they belong to, and if a catalytic site is reported in the template structure or structures that were used to build the homology model for each ORF.
It was found after superposing NDM-1 to its template structure 1ko3.pdb that the two structures share a quite similar backbone (Fig. 2B) owe to their high sequence identity percentage.
These values, compared with those of the template structure, indicate that our model has a good energetic and stereo-chemical quality as we have also found in the adiponectin model.
In Fig. 2, the sequence alignment between the ERev and the best scoring template is shown along with the secondary structures obtained from the model, template structure, and that predicted using Prof. The secondary structure obtained from the model agrees well with the predicted one.
In the resulting structure, TM5 begins with Pro1875.36 and becomes slightly tilted inward compared with the initial homology model, which was highly similar to the template structure in that region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com