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MODexplorer can be used both to explore the protein sequence, structural and functional diversity and to help in template selection in homology modeling.
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For successfully splicing multiple DNA fragments more attentions were given for primer designing, annealing temperature and templates selection in this research.
If there is wide variation in template selection and also important differences in the templates, then future refinements of the system would need to consider selection of the template as an important factor in optimizing its effects.
Experimental results on the 1000 × 6000 threading set and the CASP10 set indicate that the pairwise potential indeed improves template selection, as shown in Figures 6 and 7. On the 1000 × 6000 set, the average TM-score increases from 0.547 to 0.566 when the pairwise potential is used to rank the templates.
In template selection, the memory overhead was around 6.1 MB when 20% templates were selected to be the representatives.
In template compression, the memory overhead for template storage was the same as in template selection.
In template selection, the goal is to choose a small subset of templates as the representatives for the full set of training templates.
In the first part of this work different measures of similarity in template selection were explored and methods for homology modelling, docking and refinement of aminergic GPCR-ligand complexes were developed and evaluated by comparing models of the D3-R/eticlopride complex with the crystal structure.
To reduce any bias in template selection, a group template of images was established directly from the subject dataset.
In this section, the template selection and the polyhedron establishment will be introduced in detail.
The error of a template-based model comes from template selection and sequence-template alignment, in addition to the structure difference between the sequence and template.
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