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We chose a simple heuristic due to a lack of options, as we are not aware of any other openly available method for performing automatic pagination and template selection for variable content.
Our analysis relates only to template selection for modelling the inactive conformation of GPCRs.
Therefore these results suggest that structural information needs to be included in the decision process of template selection for homology model building.
We have performed a rigorous and systematic analysis of the available experimental GPCR structures, identifying common, different and unique sequence and structural motifs that can be used to guide template selection for homology modelling.
Combining these structural analyses with quantitative analyses of sequence similarities between the template structures has allowed us to develop workflows for template selection for each of the seven TMHs and helix 8.
The production of a multiple-sequence alignment and template selection for homology modeling were conducted as previously described by us, so here we give a brief account.
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The allocation algorithm from Fig. 9 also uses memoization in order to store the best template selections for each different sequence of elements.
This paper proposes four different approaches for dynamic optimal template selection from periocular region.
For example Figure 6B shows the suggested template selection workflow for TMH2 and is essentially a formalization of the results detailed in Table 4, Table 6 and Figure 5.
Combined with our context-specific local alignment potential, our distance-based pairwise potential can help improve both alignment accuracy and template selection especially for hard targets.
Moreover, the template selection method searches for multiple combinations of picture placement on a page, which can be costly for the generation of picture-driven documents such as photo albums, and could be disallowed for a faster algorithm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com