The converged outcome of both cytostatic and cytotoxic paradigms of S9 in vitro and in vivo, together with its appreciable anti-MDR profiles, help prove to be a promising alternative template for rational designing of anticancer drugs.
Our high-resolution crystal structure of PTP-Bas PDZ1 will serve as a useful template for rational structure-based design of novel anti-diabetes therapeutics.
In this publication we investigate the advantages and limitations of using proteins as templates for rational design of new materials.
To develop such compounds, we used QN as a template for rational chemical synthesis and created a series of over 60 novel small molecules.
The results of this study indicated that BDDE, which has unique chemical structure different from current topoisomerase I inhibitors, could serve as a lead template for rational drug design and for future anticancer agents development.
These toxins should facilitate the development of novel target-based screens for new insecticide leads, while their mapped pharmacophores will provide templates for rational design of mimetics that act at these target sites.
The strategies reported here are straightforward and extendable towards the synthesis of various pyrimidine nucleotide analogs, which could lead to compounds of value in studies of enzyme reaction mechanisms or serve as templates for rational drug design.
Conversely, models built based on low and medium similarity between the target and template sequences can be useful for functional inference, design of rational mutagenesis experiments and molecular replacement in crystallography.
Automorphisms of rational maps.
A Europe of rational hospitality.
