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To fully characterize the effects of DNA template modifications on primer extension by pol η, it is necessary to determine the sequences of full-length DNA products synthesized by the enzyme in the presence of all four dNTPs.
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Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.
X-ray structure driven template modification and exchange of the benzamidine to optimize potency and pharmacokinetic properties gave selective, potent and orally bioavailable 4- 3-aminomethyl phenyl)piperidinyl-1-amides.
To the best of the author knowledge, Co-Ni binary alloy nanowire electrodeposition in the AAO template without modification of the barrier layer has not been reported to date.
Due to this capacity to "reach" the bipolar cell layer, the AAV8 capsid was chosen as the template for modification.
Characterizing the glycome poses many challenges because there is no template for modification, as in DNA, and there is an incredible diversity of glycoforms.
However some of our innovations may serve as templates for modification and encourage researchers to develop other non-conventional approaches suited to individual research settings.
In each case, ECC M45 was used as a template, with ingredient modifications made to attain the special attributes, and then adjusted as necessary to maintain the unique tensile ductility of ECCs.
This chapter provides a brief overview of different protein nanoparticles as building blocks for the development of novel nanomaterials through chemical and genetic modifications, template synthesis, and self-assembly.
In the Arf1-GDP-ARNO
Single strand oligonucleotides with ∼50 nt long arms of homology were used as a donor template for precise modifications in zebrafish and mouse models [ 59, 70].
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