Exact(4)
The cis-3-amino-4- 2-cyanopyrrolidide -pyrrolidine cis-3-amino-4- 2-cyanopyrrolidide -pyrrolidiner inhibitors of human DPP-IV that exhibit a robust PK/PD profile.
The position of the Pot1-binding site relative to the 3′-end of the ssDNA template has been shown to have a dramatic effect on telomerase activity, with 3′-end binding blocking telomerase extension and internal binding stimulating the processivity of telomerase33.
Further, in mammalian mitochondria the transcript generated from the exogenous template has been shown to be processed and matured.
With ZnS crystals, the excitation transfer from adsorbed dye molecules to a template has been shown to proceed within picoseconds [ 169], i.e. much faster than the typical intrinsic characteristic time of photodestruction (e.g. ~20 μs for adenosine monophosphate [ 170]).
Similar(56)
Random deletion of bits that are set on in complex templates has been shown to increase compound recall, despite the associated loss in chemical information content [6].
Because amplification of long templates has been shown to be more efficient in larger emulsion droplet volumes [38], we set the oil and aqueous phase flow rates to produce droplets about 30 microns in diameter.
Multiple factors, including pairwise sequence identity between rRNA genes, number of PCR cycles, and relative abundance of gene-specific PCR templates have been shown to influence chimera formation [ 27].
In contrast, NHEJ does not require a homologous template and has been shown to be active during all stages of the cell cycle (Beucher et al. 2009).
The evolution of division of labor in an RNA-like system, from a self-replicating molecule to a transcription-like mechanism (i.e., with templates and polymerases), has been shown to evolve because it confers an increased resistance to parasites (Takeuchi et al. 2011).
38 Asn6.55 is conserved between drd1 and the template structure (adrb2) and has been shown to be important for agonist binding in adrenergic β2 receptors.
Notably, hRev1 may play a general role in bypassing many guanosine adducts because of its strong preference for incorporating dCTP regardless of the identity of the templating base, and it has been shown to have only moderately reduced efficiency when replicating bulky N- and O-alkylguanine DNA adducts.
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