This model will be useful for designing new therapies targeting the IFNα network in HIV-1-infected individuals, as well as potentially serving as a template for understanding the interaction of IFNα with other viruses.
Thus, the crystal structure of the yeast Pol α CTD B complex represents a valid structural template for understanding the interaction between catalytic and B subunits in all three polymerases.
In the same way, we utilized an extensive set of Yeast coexpression data [ 40] to investigate the coexpression tendency of those interacting Yeast proteins that served as the template for the inferred interactions in Plasmodium.
Two published experimental structures provide comparable templates for this interaction: (i) p85α SH3 in a complex with a class I PXXP peptide that is similar to PR1 (HSK RPL PPL PSL; K d of 40 μM; [ Batra-Safferling et al., 2010]) and (ii) p85α PR1 in a complex with Fyn SH3 (K d 16 μM) (Renzoni et al., 1996).
While tissue-specific exons that are alternatively spliced in a conserved fashion often code for phosphosites, the emergence of novel exons in a gene, although at first likely detrimental, is a possible template for the evolution of short interaction motifs.
Mad1/C-Mad2 at KTs is known to act as a template for the establishment of the Cdc20/C Mad2 interaction.
During the process of synthesis a non-covalent approach was used for the interaction of template and monomer.
As azobenzene itself does not contain appropriate functional groups for the interaction with the template, many research groups have developed new functionalized azobenzenes for this purpose using anilide, carboxyl, bisurea, diaminopyridine, sulfonic acid, and pyridine moieties.
People have always said Titans is about race, but it's actually a template for human interaction--maybe the perfect template.
The ePlant Molecular Interactions Viewer is a template for the visualization and analysis of biological networks in 3D using the Jmol rendering engine [24] and therefore has the advantage of deployment on the web and functional expansion through scripting.
