Sentence examples for template for structure from inspiring English sources

Since hRNase7 shares high primary sequence identity to hRNase6 and hRNase8, 58%and75%5%, respectively, its structure was used as a template for structure simulation of hRNase6 and hRNase8 which have no resolved 3D structures yet.

Three-dimensional (3D) homology model of Leishmania donovani geranylgeranyltransferase-II (LdGGTase-II) was generated by comparative modeling using MODELLER 9v8 [ 56] with crystal structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase and isoprenoid from Rattus norvegicus (PDB ID-1LTX) was selected as a template for structure modeling.

Both binding sites may serve as a template for structure-based design of novel complement therapeutics.

Our structures, along with mutagenesis and kinetic studies, provide a molecular basis for understanding pathogenic mutations and catalysis, as well as a template for structure-based drug design.

Further, we have confirmed the validity of the HTP structure as a template for structure-based drug design by predicting binding affinities for TPI and other known HTP inhibitors using in silico docking techniques.

In this study, we applied ligand docking and molecular dynamics refinement to a P2Y14R homology model to qualitatively explain structure activity relationships of previously published synthetic nucleotide analogues and to probe the quality of P2Y14R homology modeling as a template for structure-based design.

The ability to execute such ideas has made Second Story a useful template for structuring, managing and staffing a 21st-century publishing, production and communications company.

It will be of significant interest to establish whether the genotype 5a hexamer structure can similarly be used as a template for structure-guided inhibitor design.

The STICC protocol is a commonly understood template for structuring conversations, and leaders follow each of the five steps in order (Table 1).

These tools are sensitive enough to detect even very remote homologous templates for structure modeling.

Thus, the structural studies led to a deeper understanding of kinase regulation and provided new templates for structure based design of selective inhibitors.