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The structure of M. smegmatis NAT provides a template for modelling the structure of the M. tuberculosis enzyme and for structure-based ligand design as an approach to designing anti-TB drugs.
Accordingly, rhodopsin was selected as the most appropriate template for modelling the structure of the ECL2 of the TSHR TMD.
The question of whether opsin is a reliable template for modelling activated and basally active GPCRs is therefore open to discussion and is likely to remain so until additional crystal structures of active GPCRs emerge.
This paper utilises available information on the cell's chromosomal content (ploidy) as a template for modelling the role of prognostic markers in prostate cancer.
The structural coordinates of S. cerevisiae RACK1 (Asc1p) was obtained from protein databank (PBD: 3FRX) and used as a template for modelling D. discoideum RACK1.
Even the very same peptide will adopt different conformations when presented by different MHC-I alleles (13); therefore, even if the same epitope is already available in a pMHC-I crystal structure, it might not be a good template for modelling.
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Twenty years ago Trends in Biochemical Sciences published an innovative origami template for modeling the DNA double helix.
Although incomplete and despite the low structural identity with ABCG2, it could still be a proper template for modeling ABCG2, thus allowing new insights on the structural dynamics for this class of transporters.
The above equations serve as the model template for modeling hysteresis.
The structural data of the ortholog LcrV from Yersinia (PBD: 1r6f chain A) was used as a template for modeling.
The co-crystal structures of ABCB1 from the mouse model in complex with QZ59-RRR and QZ59-SSS inhibitors were used as templates for modeling site-1 and site-2, respectively; while apoprotein-ABCB1 was used as a template for modeling the site-3 and site-4.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com