Sentence examples for template conformation from inspiring English sources

An explanation based on template conformation has been proposed to account for these observations.

The monomers commonly employed in MIPs significantly alter the template conformation prior to polymerization and compromise the specific recognition of the template.

Using ROCS software,[ 9] the conformation of 1 derived from the best-fit overlay of these two molecules was chosen as the bioactive conformation of the hit, and was subsequently used as the template conformation for further overlay experiments with other structural analogues within the compound series.

In this manner, misfolded or aggregated tau might act as a template, altering the conformation of tau in each neuron that internalizes it.

Here, using sequence similarity and known 3D structure of antibody variable regions as template, the spatial conformations of 1 28 variable regions (i.e. VH and VL) were analyzed with computer-guided homology modeling methods.

In this regard, we incorporated HRN and HRC coiled-coil surface residues into a de novo designed two-stranded α-helical coiled-coil template for generating conformation-specific antibodies that recognize α-helices in proteins (Lu, S.M., Hodges, R.S., 2002. J. Biol. Chem. 277, 23515 23524).

Such competition could for instance be manifested as a series of conformational changes between interacting replicase and template until an intermolecular conformation that enables polymerization initiation is reached.

We report the design and synthesis of an insulin receptor kinase family-targeted inhibitor template using the inhibitor conformation observed in an IGF1R/inhibitor co-crystal complex by application of a novel molecular design approach that we have recently published.

Four deoxynucleotides of single-stranded DNA template fit in extended conformation within the groove formed by the exonuclease domain and N-terminal region of Pol α, in agreement with the position of template DNA upstream of the active site previously observed in other B-family DNA polymerases (Hogg et al., 2007; Swan, et al., 2009; Figure 1 figure supplement 5).

For example, pol ι induces a syn conformation on template purines, which results in a Hoogsteen base pairing with the correctly matched incoming nucleotide and enables bypass of lesions that disrupt the Watson−Crick edge but not the Hoogsteen edge (20).

To accommodate the wrong incoming nucleotide in the closed polymerase conformation, the templating base vacates the coding position with an upstream shift in the template strand.